Closing the Loop on Deep Brain Stimulation for Treatment-Resistant Depression.

ABSTRACT: Major depressive episodes are the largest cause of psychiatric disability, and can often resist treatment with medication and psychotherapy. Advances in the understanding of the neural circuit basis of depression, combined with the success of deep brain stimulation (DBS) in movement disorders, spurred several groups to test DBS for treatment-resistant depression. Multiple brain sites have now been stimulated in open-label and blinded studies. Initial open-label results were dramatic, but follow-on controlled/blinded clinical trials produced inconsistent results, with both successes and failures to meet endpoints. Data from follow-on studies suggest that this is because DBS in these trials was not targeted to achieve physiologic responses. We review these results within a technology-lifecyc

SUBMITTER: Widge AS 

PROVIDER: S-EPMC5871707 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature