Epigenetic Transgenerational Inheritance of Altered Sperm Histone Retention Sites.

ABSTRACT: A variety of environmental toxicants and factors have been shown to induce the epigenetic transgenerational inheritance of disease and phenotypic variation. Epigenetic alterations in the germline (sperm or egg) are required to transmit transgenerational phenotypes. The current study was designed to investigate the potential role of histones in sperm to help mediate the epigenetic transgenerational inheritance. The agricultural fungicide vinclozolin and the pesticide DDT (dichlorodiphenyltrichloroethane) were independently used to promote the epigenetic transgenerational inheritance of disease. Purified cauda epididymal sperm were collected from the transgenerational F3 generation control and exposure lineage male rats for histone analysis. A reproducible core of histone H3 retention sites

SUBMITTER: Ben Maamar M 

PROVIDER: S-EPMC5871750 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature