Interaction Analysis of Longevity Interventions Using Survival Curves.

ABSTRACT: A long-standing problem in ageing research is to understand how different factors contributing to longevity should be expected to act in combination under the assumption that they are independent. Standard interaction analysis compares the extension of mean lifespan achieved by a combination of interventions to the prediction under an additive or multiplicative null model, but neither model is fundamentally justified. Moreover, the target of longevity interventions is not mean life span but the entire survival curve. Here we formulate a mathematical approach for predicting the survival curve resulting from a combination of two independent interventions based on the survival curves of the individual treatments, and quantify interaction between interventions as the deviation from this predic

SUBMITTER: Nowak S 

PROVIDER: S-EPMC5872032 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature