Diversity of Cell Wall Related Proteins in Human Pathogenic Fungi.

ABSTRACT: The cell wall is one of the major keys to fungal identity. Fungi use their cell wall to sense the environment, and localize nutrients and competing microorganism. Pathogenic species additionally modify their cell walls to hide from a host's immune system. With the growing number of fungal infections and alarming shortage of available drugs, we are in need of new approaches to fight pathogens. The cell wall seems to be a natural target, since animal host cells are devoid of it. The current knowledge about fungal cell wall components is often limited, and there is huge diversity both in structure and composition between species. In order to compare the distribution of diverse proteins involved in cell wall biosynthesis and maintenance, we performed sequence homology searches against 24 funga

SUBMITTER: Muszewska A 

PROVIDER: S-EPMC5872309 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature