Oxidative stress enhances the expression of IL-33 in human airway epithelial cells.

ABSTRACT:

Background

Interleukin-33 (IL-33) is a cytokine belonging to the IL-1 family, and its possible involvement in the pathophysiology of COPD and viral-induced exacerbations has been demonstrated. IL-33 has been shown to be increased in the airway epithelial cells from COPD patients, but the regulating mechanism of IL-33 expression in airway epithelial cells remains largely unknown. In the current study, we examined whether oxidative stress, which participates in the pathogenesis of COPD, affects the expression of IL-33 in airway epithelial cells and also evaluated the effect during viral infection.

Methods

The involvement of oxidative stress in the expression of IL-33, and its signal pathway was examined after stimulation with hydrogen peroxide (H₂O₂), wit

SUBMITTER: Aizawa H 

PROVIDER: S-EPMC5872512 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature