Genetic Predictors of ≥5% Weight Loss by Multidisciplinary Advice to Severely Obese Subjects.

ABSTRACT:

Background

Weight loss success is determined by genetic factors, which may differ according to treatment strategy.

Methods

From a multidisciplinary obesity treatment program involving dietary advice, psychological counseling, and increased physical activity, 587 subjects (68% female; 46.1 ± 12.4 years; BMI 39.9 ± 6.3) were recruited. At baseline, a blood sample was drawn for DNA isolation. Genotypes were determined for 30 polymorphisms in 25 candidate genes. The association between genotypes and weight loss was assessed after 3 months (short-term) and after 12 months of treatment (long-term). Weight loss was categorized as ≥5% or <5% of initial weight.

Results

The G/G genotype of PLIN1 (rs2289487) and PLIN1 (rs2304795), the T/T genotype of PLIN1 (rs1052700), and the C

SUBMITTER: Aller EEJG 

PROVIDER: S-EPMC5872564 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature