The SAMHD1-mediated block of LINE-1 retroelements is regulated by phosphorylation.

ABSTRACT:

Background

The restriction factor SAMHD1 regulates intracellular nucleotide level by degrading dNTPs and blocks the replication of retroviruses and DNA viruses in non-cycling cells, like macrophages or dendritic cells. In patients, inactivating mutations in samhd1 are associated with the autoimmune disease Aicardi-Goutières Syndrome (AGS). The accumulation of intracellular nucleic acids derived from endogenous retroelements thriving in the absence of SAMHD1 has been discussed as potential trigger of the autoimmune reaction. In vitro, SAMHD1 has been found to restrict endogenous retroelements, like LINE-1 elements (L1). The mechanism, however, by which SAMHD1 blocks endogenous retroelements, is still unclear.

Results

Here, we show that SAMHD1 inhibits the replication o

SUBMITTER: Herrmann A 

PROVIDER: S-EPMC5872582 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature