Diurnal Variation of Sweet Taste Recognition Thresholds Is Absent in Overweight and Obese Humans.

ABSTRACT: Sweet taste thresholds are positively related to plasma leptin levels in normal weight humans: both show parallel diurnal variations and associations with postprandial glucose and insulin rises. Here, we tested whether this relationship also exists in overweight and obese (OW/Ob) individuals with hyperleptinemia. We tested 36 Japanese OW/Ob subjects (body mass index (BMI) > 25 kg/m²) for recognition thresholds for various taste stimuli at seven different time points from 8:00 a.m. to 10:00 p.m. using the staircase methodology, and measured plasma leptin, insulin, and blood glucose levels before each taste threshold measurement. We also used the homeostatic model assessment of insulin resistance (HOMA-IR) to evaluate insulin resistance. The results demonstrated that, unlike normal weight su

SUBMITTER: Sanematsu K 

PROVIDER: S-EPMC5872715 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature