Epigenetic programming of T cells impacts immune reconstitution in hematopoietic stem cell transplant recipients.

ABSTRACT: Immune reconstitution following hematopoietic stem cell transplantation (HSCT) is critical in preventing harmful sequelae in recipients with cytomegalovirus (CMV) infection. To understand the molecular mechanisms underlying immune reconstitution kinetics, we profiled the transcriptome-chromatin accessibility landscape of CMV-specific CD8⁺ T cells from HCST recipients with different immune reconstitution efficiencies. CMV-specific T cells from HSCT recipients with stable antiviral immunity expressed higher levels of interferon/defense response and cell cycle genes in an interconnected network involving PI3KCG, STAT5B, NFAT, RBPJ, and lower HDAC6, increasing chromatin accessibility at the enhancer regions of immune and T-cell receptor signaling p

SUBMITTER: Hardy K 

PROVIDER: S-EPMC5873237 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature