Growth plate expression profiling: Large and small breed dogs provide new insights in endochondral bone formation.

ABSTRACT: The difference in the adult height of mammals, and hence in endochondral bone formation, is not yet fully understood and may serve to identify targets for bone and cartilage regeneration. In line with this hypothesis, the intra-species disparity between the adult height of Great Danes and Miniature Poodles was investigated at a transcriptional level. Microarray analysis of the growth plate of five Great Danes and five Miniature Poodles revealed 2,981 unique genes that were differentially expressed, including many genes with an unknown role in skeletal development. A signaling pathway impact analysis indicated activation of the cell cycle, extracellular matrix receptor interaction and the tight junction pathway, and inhibition of pathways associated with inflammation and the complement casc

SUBMITTER: Teunissen M 

PROVIDER: S-EPMC5873274 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature