ADAM10 and γ-secretase regulate sensory regeneration in the avian vestibular organs.

ABSTRACT: The loss of sensory hair cells from the inner ear is a leading cause of hearing and balance disorders. The mammalian ear has a very limited ability to replace lost hair cells, but the inner ears of non-mammalian vertebrates can spontaneously regenerate hair cells after injury. Prior studies have shown that replacement hair cells are derived from epithelial supporting cells and that the differentiation of new hair cells is regulated by the Notch signaling pathway. The present study examined molecular influences on regeneration in the avian utricle, which has a particularly robust regenerative ability. Chicken utricles were placed in organotypic culture and hair cells were lesioned by application of the ototoxic antibiotic streptomycin. Cultures were then allowed to regenerate in vitro for s

SUBMITTER: Warchol ME 

PROVIDER: S-EPMC5873298 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature