Long term (4 years) improved insulin sensitivity following islet cell transplant in type 1 diabetes.

ABSTRACT:

Background

Impaired insulin sensitivity (IS) predicts complications and mortality in type 1 diabetes (T1D). Insulin sensitivity improves shortly after islet cell transplant for T1D, yet long-term changes in IS and associated factors such as patient characteristics, transplant factors, clinical management, and IS-related biomarkers are unknown.

Methods

Up to 9 years (mean 4) of longitudinal data were available on 22 adults (18 female) with T1D who received 1 to 3 transplants in Phase 1/2 or 3 clinical trials (2004-2014). Metabolic testing posttransplant estimated IS by the Homeostasis Model Assessment for Insulin Resistance (HOMA-IR; 111 observations) and the Simple Index of Insulin Sensitivity (SI_is ; 95 observations).

Results

Simple Index of Insulin Sensit

SUBMITTER: Rydzon B 

PROVIDER: S-EPMC5873303 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature