Low Levels of a Urinary Biomarker of Dietary Polyphenol Are Associated with Substantial Cognitive Decline over a 3-Year Period in Older Adults: The Invecchiare in Chianti Study.

ABSTRACT:

Objectives

To investigate the association between total urinary polyphenols (TUPs) and total dietary polyphenols (TDPs) and cognitive decline in an older population.

Design

The Invecchiare in Chianti (InCHIANTI) study, a cohort study with 3 years of follow-up.

Setting

Tuscany, Italy.

Participants

Individuals without dementia aged 65 and older (N=652).

Measurements

TUP and TDP concentrations were analyzed at baseline using the Folin-Ciocalteu assay and a validated food frequency questionnaire, respectively. Cognition was assessed using the Mini-Mental State Examination (MMSE) and Trail-Making Test (TMT) at baseline and after 3 years of follow-up. Substantial cognitive decline was defined as a reduction in MMSE score of three or more points and an increase

SUBMITTER: Rabassa M 

PROVIDER: S-EPMC5873306 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature