Serum leptin and risk of cognitive decline in elderly italians.

ABSTRACT:

Background

US studies suggest that leptin, a fat-derived hormone, may be protective against the development of dementia.

Objective

To investigate the complex relationship between leptin levels and cognitive decline in elderly Italians.

Methods

We studied circulating fasting leptin levels in 809 elderly adults free from dementia who participated in the prospective Italian population-based InCHIANTI study between 1998 and 2009 (mean follow-up of 8.0 years). Global cognitive decline was defined as a reduction of ≥5 points on the Mini-Mental State Examination (MMSE). Trail-Making Tests A and B were also incorporated, with cognitive decline defined as discontinued testing or the worst 10% of change from baseline. We also investigated whether any association could be explai

SUBMITTER: Littlejohns TJ 

PROVIDER: S-EPMC5873309 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature