Long-term efficacy and safety of canagliflozin in combination with insulin in Japanese patients with type 2 diabetes mellitus.

ABSTRACT:

Aim

The aim of this study was to assess the long-term efficacy and safety of canagliflozin as add-on therapy in Japanese patients with type 2 diabetes mellitus who had inadequate glycaemic control with insulin.

Materials and methods

The study comprised a 16-week, double-blind period in which patients were randomized to either placebo (P; N = 70) or canagliflozin (100 mg, CAN; N = 76), followed by a 36-week open-label period in which all patients received canagliflozin. The efficacy endpoints included the change in HbA1c from baseline to end of treatment. The safety endpoints were adverse events, hypoglycaemic events, and laboratory test values.

Results

The changes from baseline (mean ± standard deviation, last observation carried forward) in the P/CAN and CAN/CAN grou

SUBMITTER: Inagaki N 

PROVIDER: S-EPMC5873413 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature