Testing a chemical series inspired by plant stress oxylipin signalling agents for herbicide safening activity.

ABSTRACT:

Background

Herbicide safening in cereals is linked to a rapid xenobiotic response (XR), involving the induction of glutathione transferases (GSTs). The XR is also invoked by oxidized fatty acids (oxylipins) released during plant stress, suggesting a link between these signalling agents and safening. To examine this relationship, a series of compounds modelled on the oxylipins 12-oxophytodienoic acid and phytoprostane 1, varying in lipophilicity and electrophilicity, were synthesized. Compounds were then tested for their ability to invoke the XR in Arabidopsis and protect rice seedlings exposed to the herbicide pretilachlor, as compared with the safener fenclorim.

Results

Of the 21 compounds tested, three invoked the rapid GST induction associated with fenclorim. All compound

SUBMITTER: Brazier-Hicks M 

PROVIDER: S-EPMC5873417 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature