A controlled human malaria infection model enabling evaluation of transmission-blocking interventions.

ABSTRACT:

Background

Drugs and vaccines that can interrupt the transmission of Plasmodium falciparum will be important for malaria control and elimination. However, models for early clinical evaluation of candidate transmission-blocking interventions are currently unavailable. Here, we describe a new model for evaluating malaria transmission from humans to Anopheles mosquitoes using controlled human malaria infection (CHMI).

Methods

Seventeen healthy malaria-naive volunteers underwent CHMI by intravenous inoculation of P. falciparum-infected erythrocytes to initiate blood-stage infection. Seven to eight days after inoculation, participants received piperaquine (480 mg) to attenuate asexual parasite replication while allowing gametocytes to develop and mature. Primary end points were d

SUBMITTER: Collins KA 

PROVIDER: S-EPMC5873858 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature