Hypoglycemia unawareness in type 1 diabetes suppresses brain responses to hypoglycemia.

ABSTRACT:

Background

Among nondiabetic individuals, mild glucose decrements alter brain activity in regions linked to reward, motivation, and executive control. Whether these effects differ in type 1 diabetes mellitus (T1DM) patients with and without hypoglycemia awareness remains unclear.

Methods

Forty-two individuals (13 healthy control [HC] subjects, 16 T1DM individuals with hypoglycemia awareness [T1DM-Aware], and 13 T1DM individuals with hypoglycemia unawareness [T1DM-Unaware]) underwent blood oxygen level-dependent functional MRI brain imaging during a 2-step hyperinsulinemic euglycemic (90 mg/dl)-hypoglycemic (60 mg/dl) clamp for assessment of neural responses to mild hypoglycemia.

Results

Mild hypoglycemia in HC subjects altered activity in the caudate, insula, prefront

SUBMITTER: Hwang JJ 

PROVIDER: S-EPMC5873861 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature