Method for identification of condition-associated public antigen receptor sequences.

ABSTRACT: Diverse repertoires of hypervariable immunoglobulin receptors (TCR and BCR) recognize antigens in the adaptive immune system. The development of immunoglobulin receptor repertoire sequencing methods makes it possible to perform repertoire-wide disease association studies of antigen receptor sequences. We developed a statistical framework for associating receptors to disease from only a small cohort of patients, with no need for a control cohort. Our method successfully identifies previously validated Cytomegalovirus and type one diabetes responsive TCR[Formula: see text] sequences .

SUBMITTER: Pogorelyy MV 

PROVIDER: S-EPMC5873893 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature