Modifiable Risk Factors for Incident Heart Failure in Atrial Fibrillation.

ABSTRACT:

Objectives

This study sought to identify modifiable risk factors and estimate the impact of risk factor modification on heart failure (HF) risk in women with new-onset atrial fibrillation (AF).

Background

Incident HF is the most common nonfatal event in patients with AF, although strategies for HF prevention are lacking.

Methods

We assessed 34,736 participants in the Women's Health Study who were free of prevalent cardiovascular disease at baseline. Cox models with time-varying assessment of risk factors after AF diagnosis were used to identify significant modifiable risk factors for incident HF.

Results

Over a median follow-up of 20.6 years, 1,495 women developed AF without prevalent HF. In multivariable models, new-onset AF was associated with an increased ri

SUBMITTER: Chatterjee NA 

PROVIDER: S-EPMC5873947 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature