Community-acquired lower respiratory tract infections in HIV-infected patients on antiretroviral therapy: predictors in a contemporary cohort study.

ABSTRACT: Community-acquired pneumonia represents the most frequent bacterial infection in patients with HIV/AIDS.

Purpose

We aimed to assess variables associated with lower respiratory tract infection (LRTI) among HIV-infected adults using ART.

Methods

A cohort study of HIV-infected patients aged ≥18 years, enrolled from 2000 to 2015, on ART for at least 60 days, with primary outcome as the 1st episode of LRTI during follow-up. The independent variables included were sex at birth, age, race/skin color, educational level, tobacco smoking, alcohol use, cocaine use, diabetes mellitus, CD4 count, HIV viral load, influenza and pneumococcal vaccination. Extended Cox proportional hazards models accounting for time-updated variables were fitted to assess LRTI predictors.

Results

2669 p

SUBMITTER: Lamas CC 

PROVIDER: S-EPMC5873951 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature