Retrospective harm benefit analysis of pre-clinical animal research for six treatment interventions.

ABSTRACT:

Background

The harm benefit analysis (HBA) is the cornerstone of animal research regulation and is considered to be a key ethical safeguard for animals. The HBA involves weighing the anticipated benefits of animal research against its predicted harms to animals but there are doubts about how objective and accountable this process is.

Objectives

i. To explore the harms to animals involved in pre-clinical animal studies and to assess these against the benefits for humans accruing from these studies; ii. To test the feasibility of conducting this type of retrospective HBA.

Methods

Data on harms were systematically extracted from a sample of pre-clinical animal studies whose clinical relevance had already been investigated by comparing systematic reviews of the animal stu

SUBMITTER: Pound P 

PROVIDER: S-EPMC5874012 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature