Differential models of twin correlations in skew for body-mass index (BMI).

ABSTRACT: BACKGROUND:Body Mass Index (BMI), like most human phenotypes, is substantially heritable. However, BMI is not normally distributed; the skew appears to be structural, and increases as a function of age. Moreover, twin correlations for BMI commonly violate the assumptions of the most common variety of the classical twin model, with the MZ twin correlation greater than twice the DZ correlation. This study aimed to decompose twin correlations for BMI using more general skew-t distributions. METHODS:Same sex MZ and DZ twin pairs (N = 7,086) from the community-based Washington State Twin Registry were included. We used latent profile analysis (LPA) to decompose twin correlations for BMI into multiple mixture distributions. LPA was performed using the default normal mixture distribution and the

SUBMITTER: Tsang S 

PROVIDER: S-EPMC5874062 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature