Default mode network deactivation to smoking cue relative to food cue predicts treatment outcome in nicotine use disorder.

ABSTRACT: Identifying predictors of treatment outcome for nicotine use disorders (NUDs) may help improve efficacy of established treatments, like varenicline. Brain reactivity to drug stimuli predicts relapse risk in nicotine and other substance use disorders in some studies. Activity in the default mode network (DMN) is affected by drug cues and other palatable cues, but its clinical significance is unclear. In this study, 143 individuals with NUD (male n = 91, ages 18-55 years) received a functional magnetic resonance imaging scan during a visual cue task during which they were presented with a series of smoking-related or food-related video clips prior to randomization to treatment with varenicline (n = 80) or placebo. Group independent components analysis was utilized to isolate the DMN, and tem

SUBMITTER: Wilcox CE 

PROVIDER: S-EPMC5874131 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature