Phylogenetic analysis and virulence determinant of the host-adapted Staphylococcus aureus lineage ST188 in China.

ABSTRACT: Staphylococcus aureus (S. aureus) is an important pathogen of humans and livestock species, but an understanding of the clonal distribution of S. aureus causing different host-species infections in the same geographical environment and within the same period is lacking. By characterizing infections caused by S. aureus in bovine, pediatric, and adult patients in Shanghai, China, between 2012 and 2014, we identified methicillin-sensitive S. aureus (MSSA) ST188 as the major lineage causing infections in multiple host species. Whole-genome sequencing and phenotypic analyses demonstrated that ST188 might evolve from livestock, and there was no significant genomic or virulence difference between ST188 isolated from livestock and humans. The virulence of ST188 is related to its adhesion and nasal

SUBMITTER: Wang Y 

PROVIDER: S-EPMC5874244 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature