Systems-Level Feedbacks of NRF2 Controlling Autophagy upon Oxidative Stress Response.

ABSTRACT: Although the primary role of autophagy-dependent cellular self-eating is cytoprotective upon various stress events (such as starvation, oxidative stress, and high temperatures), sustained autophagy might lead to cell death. A transcription factor called NRF2 (nuclear factor erythroid-related factor 2) seems to be essential in maintaining cellular homeostasis in the presence of either reactive oxygen or nitrogen species generated by internal metabolism or external exposure. Accumulating experimental evidence reveals that oxidative stress also influences the balance of the 5' AMP-activated protein kinase (AMPK)/rapamycin (mammalian kinase target of rapamycin or mTOR) signaling pathway, thereby inducing autophagy. Based on computational modeling here we propose that the regulatory triangle of

SUBMITTER: Kapuy O 

PROVIDER: S-EPMC5874525 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature