Dosimetric and radiobiological comparison for quality assurance of IMRT and VMAT plans.

ABSTRACT:

Introduction

The gamma analysis used for quality assurance of a complex radiotherapy plan examines the dosimetric equivalence between planned and measured dose distributions within some tolerance. This study explores whether the dosimetric difference is correlated with any radiobiological difference between delivered and planned dose.

Methods

VMAT or IMRT plans optimized for 14 cancer patients were calculated and delivered to a QA device. Measured dose was compared against planned dose using 2-D gamma analysis. Dose volume histograms (for various patient structures) obtained by interpolating measured data were compared against the planned ones using a 3-D gamma analysis. Dose volume histograms were used in the Poisson model to calculate tumor control probability for the trea

SUBMITTER: Paudel NR 

PROVIDER: S-EPMC5874955 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature