The Potential of Angiogenin as a Serum Biomarker for Diseases: Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Angiogenin (ANG) is a multifunctional angiogenic protein that participates in both normal development and diseases. Abnormal serum ANG levels are commonly reported in various diseases. However, whether ANG can serve as a diagnostic or prognostic marker for different diseases remains a matter of debate.

Methods

Here, we performed a systematic review and meta-analysis of the literature utilizing PubMed, Web of Science, and Scopus search engines to identify all publications comparing plasma or serum ANG levels between patients with different diseases and healthy controls, as were studies evaluating circulating ANG levels in healthy populations, pregnant women, or other demographic populations.

Results

This study demonstrated that the serum ANG concentration in

SUBMITTER: Yu D 

PROVIDER: S-EPMC5875026 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature