Vascular endothelial growth factor gene variations as a risk predictor in disc degeneration.

ABSTRACT:

Objective

To evaluate the frequency of polymorphisms in the vascular endothelial growth factor (VEGF) gene, as well as to identify a potential risk haplotype among the polymorphic regions in this gene in patients with disc degeneration and in the Control Group.

Methods

This study analyzed a total of 217 individuals distributed into the Disc Degeneration and Control Groups. Peripheral blood was collected from all patients to detect VEGF gene polymorphisms identified by qPCR (rs699947, rs1570360, rs2010963, rs833061 and rs3025039). All patients presenting disc degeneration had the confirmation by nuclear magnetic resonance test and were rated according to disc degeneration level.

Results

All polymorphisms were in Hardy- Weinberg equilibrium (p>0.05) in the studied popul

SUBMITTER: Amaro A 

PROVIDER: S-EPMC5875151 | biostudies-literature | 2017 Oct-Dec

REPOSITORIES: biostudies-literature