Enhanced Replication of Highly Pathogenic Influenza A(H7N9) Virus in Humans.

ABSTRACT: To clarify the threat posed by emergence of highly pathogenic influenza A(H7N9) virus infection among humans, we characterized the viral polymerase complex. Polymerase basic 2-482R, polymerase basic 2-588V, and polymerase acidic-497R individually or additively enhanced virus polymerase activity, indicating that multiple replication-enhancing mutations in 1 isolate may contribute to virulence.

SUBMITTER: Yamayoshi S 

PROVIDER: S-EPMC5875272 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature