Roles of Birth Mode and Infant Gut Microbiota in Intergenerational Transmission of Overweight and Obesity From Mother to Offspring.

ABSTRACT:

Importance

Maternal overweight, which often results in cesarean delivery, is a strong risk factor for child overweight. Little is known about the joint contribution of birth mode and microbiota in the infant gut to the association between maternal prepregnancy overweight and child overweight.

Objective

To investigate the association of birth mode with microbiota in the infant gut, and whether this mediates the association between maternal and child overweight.

Design, setting, and participants

An observational study was conducted of 935 full-term infants born between January 1, 2009, and December 31, 2012, in the Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort. Maternal prepregnancy body mass index (BMI) was calculated as weight in kilograms divi

SUBMITTER: Tun HM 

PROVIDER: S-EPMC5875322 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature