Comparative Effectiveness of Levetiracetam vs Phenobarbital for Infantile Epilepsy.

ABSTRACT:

Importance

More than half of infants with new-onset epilepsy have electroencephalographic and clinical features that do not conform to known electroclinical syndromes (ie, nonsyndromic epilepsy). Levetiracetam and phenobarbital are the most commonly prescribed medications for epilepsy in infants, but their comparative effectiveness is unknown.

Objective

To compare the effectiveness of levetiracetam vs phenobarbital for nonsyndromic infantile epilepsy.

Design, setting, and participants

The Early Life Epilepsy Study-a prospective, multicenter, observational cohort study conducted from March 1, 2012, to April 30, 2015, in 17 US medical centers-enrolled infants with nonsyndromic epilepsy and a first afebrile seizure between 1 month and 1 year of age.

Exposures

Use

SUBMITTER: Grinspan ZM 

PROVIDER: S-EPMC5875334 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature