Association of Childhood Infection With IQ and Adult Nonaffective Psychosis in Swedish Men: A Population-Based Longitudinal Cohort and Co-relative Study.

ABSTRACT:

Importance

Associations between childhood infection, IQ, and adult nonaffective psychosis (NAP) are well established. However, examination of sensitive periods for exposure, effect of familial confounding, and whether IQ provides a link between childhood infection and adult NAP may elucidate pathogenesis of psychosis further.

Objectives

To test the association of childhood infection with IQ and adult NAP, to find whether shared familial confounding explains the infection-NAP and IQ-NAP associations, and to examine whether IQ mediates and/or moderates the childhood infection-NAP association.

Design, setting, and participants

Population-based longitudinal cohort study using linkage of Swedish national registers. The risk set included all Swedish men born between 1973 an

SUBMITTER: Khandaker GM 

PROVIDER: S-EPMC5875340 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature