Neural Markers of Resilience in Adolescent Females at Familial Risk for Major Depressive Disorder.

ABSTRACT:

Importance

Adolescence is a neurodevelopmental period during which experience-dependent plasticity in brain circuitry may confer vulnerability to depression as well as resilience to disorder. Little is known, however, about the neural mechanisms that underlie resilience during this critical period of brain development.

Objective

To examine neural functional connectivity correlates of resilience in adolescent females at high and low familial risk for depression who did and did not develop the disorder.

Design, setting, and participants

A longitudinal study was conducted at Stanford University from October 1, 2003, to January 31, 2017. Sixty-five female adolescents participated in the study: 20 at high risk in whom depression did not develop (resilient), 20 at high risk

SUBMITTER: Fischer AS 

PROVIDER: S-EPMC5875355 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature