Association of Brain Cortical Changes With Relapse in Patients With Major Depressive Disorder.

ABSTRACT:

Importance

More than half of all patients with major depressive disorder (MDD) experience a relapse within 2 years after recovery. It is unclear how relapse affects brain morphologic features during the course of MDD.

Objective

To use structural magnetic resonance imaging to identify morphologic brain changes associated with relapse in MDD.

Design, setting, and participants

In this longitudinal case-control study, patients with acute MDD at baseline and healthy controls were recruited from the University of Münster Department of Psychiatry from March 21, 2010, to November 14, 2014, and were reassessed from November 11, 2012, to October 28, 2016. Depending on patients' course of illness during follow-up, they were subdivided into groups of patients with and without rel

SUBMITTER: Zaremba D 

PROVIDER: S-EPMC5875383 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature