Classification of histologically scored human knee osteochondral plugs by quantitative analysis of magnetic resonance images at 3T.

ABSTRACT: This work evaluates the ability of quantitative MRI to discriminate between normal and pathological human osteochondral plugs characterized by the Osteoarthritis Research Society International (OARSI) histological system. Normal and osteoarthritic human osteochondral plugs were scored using the OARSI histological system and imaged at 3 T using MRI sequences producing T1 and T2 contrast and measuring T1, T2, and T2* relaxation times, magnetization transfer, and diffusion. The classification accuracies of quantitative MRI parameters and corresponding weighted image intensities were evaluated. Classification models based on the Mahalanobis distance metric for each MRI measurement were trained and validated using leave-one-out cross-validation with plugs grouped according to OARSI histological

SUBMITTER: Lukas VA 

PROVIDER: S-EPMC5875433 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature