Association of proton pump inhibitor use with renal outcomes in patients with coronary artery disease.

ABSTRACT:

Background

Several studies have suggested that proton pump inhibitor (PPI) use is associated with adverse renal outcomes, but obvious evidence for this association is lacking. We investigated the association between PPI use and adverse renal outcomes in patients who had undergone percutaneous coronary intervention.

Methods

Of the 1,284 patients hospitalized for percutaneous coronary intervention between January 2007 and May 2012, 934 patients with baseline estimated glomerular filtration rate greater than 60 mL/min/1.73 m² were enrolled. Multivariable Cox models were used to examine whether PPI use was associated with acute and chronic adverse renal outcomes.

Results

In adjusted time-dependent Cox models, PPI use was associated with acute kidney injury (haz

SUBMITTER: Cho NJ 

PROVIDER: S-EPMC5875577 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature