Effects of vaccines in patients with sickle cell disease: a systematic review protocol.

ABSTRACT:

Introduction

Sickle cell disease (SCD) is an inherited haematological disorder caused by a single point mutation (Glub6Val) that promotes polymerisation of haemoglobin S and sickling of erythrocytes. Inflammation, haemolysis, microvascular obstruction and organ damage characterise the highly variable clinical expression of SCD. People with SCD are at increased risk of severe infections, hence the need for vaccination against common disease-causing organisms in this population. We aim to review the evidence on the efficacy and safety of vaccines in people with SCD.

Methods and analysis

The present systematic review will examine the current data as indexed in PubMed, CENTRAL, EMBASE and EBSCOHost. We will consult Strategic Advisory Group of Experts practice statements, confere

SUBMITTER: Wiyeh AB 

PROVIDER: S-EPMC5875604 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature