Lifestyle and vascular risk effects on MRI-based biomarkers of Alzheimer's disease: a cross-sectional study of middle-aged adults from the broader New York City area.

ABSTRACT:

Objective

To investigate the effects of lifestyle and vascular-related risk factors for Alzheimer's disease (AD) on in vivo MRI-based brain atrophy in asymptomatic young to middle-aged adults.

Design

Cross-sectional, observational.

Setting

Broader New York City area. Two research centres affiliated with the Alzheimer's disease Core Center at New York University School of Medicine.

Participants

We studied 116 cognitively normal healthy research participants aged 30-60 years, who completed a three-dimensional T1-weighted volumetric MRI and had lifestyle (diet, physical activity and intellectual enrichment), vascular risk (overweight, hypertension, insulin resistance, elevated cholesterol and homocysteine) and cognition (memory, executive function, language) data.

SUBMITTER: Mosconi L 

PROVIDER: S-EPMC5875649 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature