Effectiveness of blood pressure-lowering drug treatment by levels of absolute risk: post hoc analysis of the Australian National Blood Pressure Study.

ABSTRACT:

Objectives

In many current guidelines, blood pressure (BP)-lowering drug treatment for primary prevention of cardiovascular disease (CVD) is based on absolute risk. However, in clinical practice, therapeutic decisions are often based on BP levels alone. We sought to investigate which approach was superior by conducting a post hoc analysis of the Australian National Blood Pressure (ANBP) cohort, a seminal study establishing the efficacy of BP lowering in 'mild hypertensive' persons.

Design

A post hoc subgroup analysis of the ANBP trial results by baseline absolute risk tertile.

Setting and participants

3244 participants aged 35-69 years in a community-based randomised placebo controlled trial of blood pressure-lowering medication.

Interventions

Chlorothiazide500

SUBMITTER: Ho CLB 

PROVIDER: S-EPMC5875665 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature