Targeting skeletal muscle tissue oxygenation (StO₂) in adults with severe sepsis and septic shock: a randomised controlled trial (OTO-StS Study).

ABSTRACT:

Objective

Evaluation of the ratio of oxyhaemoglobin to total haemoglobin in skeletal muscle (StO₂) using near-infrared spectroscopy may aid in the monitoring of patients with sepsis. This study assessed the benefits and risks of targeting StO₂ in adults with severe sepsis or septic shock.

Design

A European randomised controlled trial was performed on two parallel groups.

Setting

Five intensive care units (ICU) in France, Greece, Spain and Germany were used for the study.

Participants

A total of 103 adults with severe sepsis or septic shock on ICU admission were randomised (54 subjects in the experimental arm and 49 subjects in the control arm).

Interventions

Haemodynamic management using an algorithm that was adapted from the 2004 S

SUBMITTER: Nardi O 

PROVIDER: S-EPMC5875667 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature