The 'COmorBidity in Relation to AIDS' (COBRA) cohort: Design, methods and participant characteristics.

ABSTRACT:

Background

Persons living with HIV on combination antiretroviral therapy (cART) may be at increased risk of the development of age-associated non-communicable comorbidities (AANCC) at relatively young age. It has therefore been hypothesised that such individuals, despite effective cART, may be prone to accelerated aging.

Objective

The COmorBidity in Relation to AIDS (COBRA) cohort study was designed to investigate the potential causal link between HIV and AANCC, amongst others, in a cohort of middle-aged individuals with HIV with sustained viral suppression on cART and otherwise comparable HIV-negative controls.

Methods

Longitudinal cohort study of HIV-positive subjects ≥45 years of age, with sustained HIV suppression on cART recruited from two large European HIV trea

SUBMITTER: De Francesco D 

PROVIDER: S-EPMC5875743 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature