Serum anti-glycan-antibodies in relatives of patients with inflammatory bowel disease.

ABSTRACT:

Background

Serum anti-glycan antibodies are a promising tool for differential diagnosis, disease stratification and prediction of Crohn's disease (CD). To investigate possible heritability of the markers we assessed the presence of serum anti-glycan antibodies in affected and unaffected relatives of patients with CD.

Methods

Serum samples of 169 IBD patients of the German inflammatory bowel disease (IBD) network (140 CD & 29 Ulcerative colitis (UC)), 349 relatives of CD patients, 63 relatives of UC patients and 46 healthy controls were tested for the presence of anti-glycan antibodies by ELISA in a blinded fashion. Clinical data of the IBD patients and controls were available.

Results

A higher proportion of non-affected CD relatives was positive for anti-glycan antibo

SUBMITTER: Kamm F 

PROVIDER: S-EPMC5875751 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature