Integrated analysis of tumor differentiation genes in pancreatic adenocarcinoma.

ABSTRACT:

Background

Tumor differentiation is an important process in the development of cancer. It is valuable to identify key differentiation related genes in the prognosis and therapy of pancreatic adenocarcinoma.

Methods

The mRNA expression data were downloaded from the Cancer Genome Atlas database. Then, differentially expressed tumor differentiation related genes were identified. Additionally, Gene Ontology functional categories and Kyoto Encyclopedia of Genes and Genomes biochemical pathway was used to explore the function. In addition, receiver operating characteristic and survival analysis were carried out to assess the diagnosis and prognosis value. Finally, the electronic validation of selected tumor differentiation related genes was performed.

Results

A total of 932

SUBMITTER: Xi T 

PROVIDER: S-EPMC5875763 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature