The Pathway Coexpression Network: Revealing pathway relationships.

ABSTRACT: A goal of genomics is to understand the relationships between biological processes. Pathways contribute to functional interplay within biological processes through complex but poorly understood interactions. However, limited functional references for global pathway relationships exist. Pathways from databases such as KEGG and Reactome provide discrete annotations of biological processes. Their relationships are currently either inferred from gene set enrichment within specific experiments, or by simple overlap, linking pathway annotations that have genes in common. Here, we provide a unifying interpretation of functional interaction between pathways by systematically quantifying coexpression between 1,330 canonical pathways from the Molecular Signatures Database (MSigDB) to establish the P

SUBMITTER: Pita-Juarez Y 

PROVIDER: S-EPMC5875878 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature