APOL1 Genotype and Renal Function of Black Living Donors.

ABSTRACT: Black living kidney donors are at higher risk of developing kidney disease than white donors. We examined the effect of the APOL1 high-risk genotype on postdonation renal function in black living kidney donors and evaluated whether this genotype alters the association between donation and donor outcome. We grouped 136 black living kidney donors as APOL1 high-risk (two risk alleles; n=19; 14%) or low-risk (one or zero risk alleles; n=117; 86%) genotype. Predonation characteristics were similar between groups, except for lower mean±SD baseline eGFR (CKD-EPI equation) in donors with the APOL1 high-risk genotype (98±17 versus 108±20 ml/min per 1.73 m²; P=0.04). At a median of 12 years after donation, donors with the APOL1 high-risk ge

SUBMITTER: Doshi MD 

PROVIDER: S-EPMC5875947 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature