Hemodialysis Induces an Acute Decline in Cerebral Blood Flow in Elderly Patients.

ABSTRACT: The initiation of hemodialysis is associated with an accelerated decline of cognitive function and an increased incidence of cerebrovascular accidents and white matter lesions. Investigators have hypothesized that the repetitive circulatory stress of hemodialysis induces ischemic cerebral injury, but the mechanism is unclear. We studied the acute effect of conventional hemodialysis on cerebral blood flow (CBF), measured by [¹⁵O]H₂O positron emission tomography-computed tomography (PET-CT). During a single hemodialysis session, three [¹⁵O]H₂O PET-CT scans were performed: before, early after the start of, and at the end of hemodialysis. We used linear mixed models to study global and regional CBF change during hemodialysis. Twelve patients aged ≥65

SUBMITTER: Polinder-Bos HA 

PROVIDER: S-EPMC5875962 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature