A rapid T₁ mapping method for assessment of murine kidney viability using dynamic manganese-enhanced magnetic resonance imaging.

ABSTRACT:

Purpose

Dynamic manganese-enhanced MRI (MEMRI) allows assessment of tissue viability by tracing manganese uptake. We aimed to develop a rapid T₁ mapping method for dynamic MEMRI to facilitate assessments of murine kidney viability.

Methods

A multi-slice saturation recovery fast spin echo (MSRFSE) was developed, validated, and subsequently applied in dynamic MEMRI at 16.4T on ischemic mouse kidneys after 4 weeks of unilateral renal artery stenosis (RAS). Baseline T₁ values and post-contrast R₁ (1/T₁ ) changes were measured in cortex (CO), outer (OSOM), inner (ISOM) strips of outer medulla, and inner medulla (IM).

Results

Validation studies showed strong agreement between MSRFSE and an established saturation recovery Look-Lock

SUBMITTER: Jiang K 

PROVIDER: S-EPMC5876081 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature