Trans-ethnic analysis of metabochip data identifies two new loci associated with BMI.

ABSTRACT:

Objective

Body mass index (BMI) is commonly used to assess obesity, which is associated with numerous diseases and negative health outcomes. BMI has been shown to be a heritable, polygenic trait, with close to 100 loci previously identified and replicated in multiple populations. We aim to replicate known BMI loci and identify novel associations in a trans-ethnic study population.

Subjects

Using eligible participants from the Population Architecture using Genomics and Epidemiology consortium, we conducted a trans-ethnic meta-analysis of 102 514 African Americans, Hispanics, Asian/Native Hawaiian, Native Americans and European Americans. Participants were genotyped on over 200 000 SNPs on the Illumina Metabochip custom array, or imputed into the 1000 Genomes Project (Phase I)

SUBMITTER: Gong J 

PROVIDER: S-EPMC5876082 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature