Post-GWAS in Psychiatric Genetics: A Developmental Perspective on the "Other" Next Steps.

ABSTRACT: As psychiatric genetics enters an era where gene identification is finally yielding robust, replicable genetic associations and polygenic risk scores, it is important to consider next steps and delineate how that knowledge will be applied to ultimately ameliorate suffering associated with substance use and psychiatric disorders. Much of the post-genome-wide association study discussion has focused on the potential of genetic information to elucidate the underlying biology and use this information for the development of more effective pharmaceutical treatments. In this review we focus on additional areas of research that should follow gene identification. By taking genetic findings into longitudinal, developmental studies, we can map the pathways by which genetic risk manifests across devel

SUBMITTER: Dick DM 

PROVIDER: S-EPMC5876087 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature